Table 2 |
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Summary of effects of PALMs on cells of the innate and adoptive immune system |
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PMN |
Eosinophils |
Dendritic cells |
|
|
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|
Chemotaxis* |
Chemotaxis# |
IL-12¶↓ |
|
Calcium influx* |
TH2 bias in MLR¶ |
|
|
CD11b*↑ |
CD11b#↑ |
cAMPi§↑ |
|
Release of MPO*↑ |
Release of ECP↑# |
CXCR4§↑ |
|
CCR5, CCR1§↓ |
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|
CCL22§↑ |
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|
CXCL10, CCL5↓§ |
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|
|
||
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Arrows indicate an increase (↑) or decrease (↓). References: *: Traidl-Hoffmann C et al., J Allergy Clin Immunol (2002); #: Plötz SG et al., J Allergy Clin Immunol (2004); ¶: Traidl-Hoffmann C et al., J Exp Med (2005); §: Mariani V et al., J Immunol (2007) cAMPi = intracellular cyclic 5'-adenosine monophosphate; ECP = eosinophil cationic protein; MLR = mixed lymphocyte reaction. |
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Gilles et al. Allergy, Asthma & Clinical Immunology 2009 5:3 doi:10.1186/1710-1492-5-3 |
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