Table 2

Summary of effects of PALMs on cells of the innate and adoptive immune system

PMN

Eosinophils

Dendritic cells


Chemotaxis*

Chemotaxis#

IL-12¶↓

Calcium influx*

TH2 bias in MLR

CD11b*↑

CD11b#↑

cAMPi§↑

Release of MPO*

Release of ECP↑#

CXCR4§↑

CCR5, CCR1§↓

CCL22§↑

CXCL10, CCL5↓§


Arrows indicate an increase (↑) or decrease (↓).

References: *: Traidl-Hoffmann C et al., J Allergy Clin Immunol (2002); #: Plötz SG et al., J Allergy Clin Immunol (2004); : Traidl-Hoffmann C et al., J Exp Med (2005); §: Mariani V et al., J Immunol (2007)

cAMPi = intracellular cyclic 5'-adenosine monophosphate; ECP = eosinophil cationic protein; MLR = mixed lymphocyte reaction.

Gilles et al. Allergy, Asthma & Clinical Immunology 2009 5:3   doi:10.1186/1710-1492-5-3

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