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Factor XII mutations, estrogen-dependent inherited angioedema, and related conditions

Karen E Binkley

Author Affiliations

Division of Clinical Immunology and Allergy, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Allergy, Asthma & Clinical Immunology 2010, 6:16  doi:10.1186/1710-1492-6-16

Published: 28 July 2010


The clinical, biochemical and genetic features of the conditions known as estrogen-dependent inherited angioedema, estrogen-associated angioedema, hereditary angioedema with normal C-1 inhibitor, type III angioedema, or factor XII angioedema are reviewed. Discussion emphasizes pathogenesis, diagnosis, and management.