Table 1

Pharmacokinetics of pasteurized pd C1-INH Concentrate (median values)

Incremental IVR

[%rise/U/kg bw]

Tmax

[hr]

T 1/2

[hr]

MRT

[hr]

AUC

[U*hr/mL]

Clearance

[mL/kg*hr]

Vss

[mL/kg]

Children on Demand n = 6

2.2

0.6

32.9

47.5

13.4

1.1

50.0

Adults on Demand n = 19

2.0

1.0

39.1

56.5

16.7

0.9

56.5

Adults IRT n = 15

2.9*

0.5

30.9**

44.6**

15.7

1.0

37.5***

*p = 0.006, ** p = 0.052, *** p = 0.004, statistically significant differences of Adults IRT vs. Adults on demand

IVR = in vivo recovery

Tmax = Median time to maximum functional pd C1-INH level

T1/2 = Terminal elimination half-life

MRT = Mean residence time

AUC = area under the curve

Vss = Volume of distribution at steady state

Aygören-Pürsün et al. Allergy, Asthma & Clinical Immunology 2010 6:21   doi:10.1186/1710-1492-6-21