Review
HAE international home therapy consensus document
1 Department of Immunology, Barts and the London NHS Trust, London, UK
2 3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
3 Departments of Medicine and Pediatrics, Penn State University, Hershey, Pennsylvania, USA
4 Johann Wolfgang Goethe University, Frankfurt/Main, Germany
5 Department of Immunology, Plymouth Hospitals NHS Trust, UK
6 Dept of Internal Medicin, Ryhov County Hospital, SE-55185 Jönköping, Sweden
7 Department of Dermatology, University Hospital of the Johannes Gutenberg-University of Mainz, Mainz, Germany
8 Department of Medicine, CHU de Grenoble, Grenoble, France
9 Executive Director, HAE International, Denmark
10 Department of Dermatology and Allergy Centre, Odense University Hospital, Denmark
11 Hospital La Paz Health Research Institute, Madrid, Spain
12 Department of Internal Medicine, Universita degli Studi di Milano, Ospedale L. Sacco, Milan, Italy
13 Department of Immunology, Barts and the London NHS Trust, London, UK
14 Department of Immunology, Southmead Hospital, Bristol, UK
15 Department of Immunology, St James' Hospital, Leeds, UK
16 Department of Immunology, Barts and the London NHS Trust, London, UK
17 HAE association, Germany
18 Johann Wolfgang Goethe University, Frankfurt/Main, Germany
19 Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
20 US HAEA Executive Vice President; US HAEA Patient Registry, USA
21 Johann Wolfgang Goethe University, Frankfurt/Main, Germany
22 HAE Association, France
23 Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
24 Departments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta, Canada
25 University of California, San Diego, San Diego, California, USA
Allergy, Asthma & Clinical Immunology 2010, 6:22 doi:10.1186/1710-1492-6-22
Published: 28 July 2010Abstract
Hereditary angioedema (C1 inhibitor deficiency, HAE) is associated with intermittent swellings which are disabling and may be fatal. Effective treatments are available and these are most useful when given early in the course of the swelling. The requirement to attend a medical facility for parenteral treatment results in delays. Home therapy offers the possibility of earlier treatment and better symptom control, enabling patients to live more healthy, productive lives. This paper examines the evidence for patient-controlled home treatment of acute attacks ('self or assisted administration') and suggests a framework for patients and physicians interested in participating in home or self-administration programmes. It represents the opinion of the authors who have a wide range of expert experience in the management of HAE.
