Table 7 |
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|
Multivariate repeated measurement analysis of the association of positive skin prick test (SPT) at ages 4, 10 and 18 with IL13 and prenatal factors, stratified by birth order (n = 825; obs = 1,305) (PR = Prevalence Ratio) |
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|
1st Born |
2nd Born |
3rd and Higher |
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|
Study Variables |
p |
PR (95% CI) |
p |
PR (95% CI) |
p |
PR (95% CI) |
|
|
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|
(n = 354; obs = 772)# |
(n = 287; obs = 634) |
(n = 184; obs = 414) |
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|
rs20541: |
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|
-AA/GA vs. GG |
0.007 |
1.35 (1.09, 1.69) |
0.045 |
0.75 (0.56, 0.99) |
0.075 |
1.35 (0.97, 1.89) |
|
Gender (M vs. F) |
0.014 |
1.32 (1.06, 1.66) |
0.001 |
1.50 (1.18, 1.89) |
0.082 |
1.34 (0.96, 1.85) |
|
Environmental Smoke Exposure*: |
||||||
|
- ETS-1 vs. ETS-0 |
0.577 |
0.93 (0.73, 1.19) |
0.698 |
1.05 (0.81, 1.36) |
0.179 |
0.76 (0.52, 1.13) |
|
- ETS-2 vs. ETS-0 |
0.020 |
0.65 (0.45, 0.93) |
0.101 |
0.75 (0.53, 1.06) |
0.309 |
0.79 (0.50, 1.25) |
|
Family SES Cluster**: |
||||||
|
- Low vs. High |
0.099 |
1.51 (0.93, 2.45) |
0.331 |
0.73 (0.39, 1.38) |
0.006 |
0.34 (0.16, 1.37) |
|
- Middle vs. High |
0.741 |
1.07 (0.70, 1.64) |
0.355 |
1.24 (0.78, 1.97) |
0.091 |
0.67 (0.43, 1.06) |
|
Gestational Age |
0.377 |
0.96 (0.89, 1.04) |
0.033 |
1.10 (1.01, 1.21) |
0.010 |
1.24 (1.05, 1.47) |
|
|
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|
# 354 children provided 772 observations because SPT was assessed at 3 separate time-points - 4, 10 and 18 years. * ETS-0: mother did not smoke during pregnancy and children not exposed to household ETS; ETS-1: mother did not smoke during pregnancy, but children were exposed to household ETS; ETS-2: mother smoked during pregnancy and children were exposed to household ETS. **"Family social status cluster" is a composite variable derived from a combination of family income, parental occupation (socioeconomic status), and number of children in child's bedroom. |
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|
Ogbuanu et al. Allergy, Asthma & Clinical Immunology 2010 6:6 doi:10.1186/1710-1492-6-6 |
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