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Long-term benefits of omalizumab in a patient with severe non-allergic asthma

Francesco Menzella*, Roberto Piro, Nicola Facciolongo, Claudia Castagnetti, Anna Simonazzi and Luigi Zucchi

Author Affiliations

Department of Respiratory Diseases, Santa Maria Nuova Hospital, Reggio, Emilia, Italy

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Allergy, Asthma & Clinical Immunology 2011, 7:9  doi:10.1186/1710-1492-7-9

Published: 24 May 2011



Currently, omalizumab is indicated for the treatment of patients with severe allergic uncontrolled asthma despite optimal therapy.

Case presentation

We studied a 52-year-old man who has been suffering from severe non allergic steroid-resistant asthma with increased levels of total IgE and a lot of comorbidity. After a 3 years long treatment with omalizumab, he presented a significant improvement in disease control in terms of hospitalizations, exacerbation, quality of life and lung function with good safety profile.


Our case shows, after a long follow-up, how omalizumab can be effective in a severe form of non-atopic asthma. It is therefore hoped that further studies can identify indicators that are able to give to clinicians information about patients who can be responsive to monoclonal anti-IgE antibody even if non allergic.