Table 5

Conditions to consider in the differential diagnosis of drug allergy. [5]

IgE-mediated drug allergy

(urticaria, angioedema, anaphylaxis, bronchospasm):

• Carcinoid syndrome

• Insect bites/stings

• Mastocytosis

• Asthma

• Food allergy

• Scombroid fish poisoning

• Latex allergy

• Infection (EBV, hepatitis A, B, C, gastrointestinal parasites)

Non-IgE mediated reactions

(exanthema, DRESS, SJS, TEN):

• Acute graft-versus-host disease

• Kawasaki disease

• Still’s disease

• Psoriasis

• Insect bites/stings

• Viral infection

• Streptococcal infection


IgE: immunoglobulin E; EBV: Epstein-Barr virus; SJS: Stevens-Johnson syndrome; TEN: toxic epidermal necrolysis; DRESS: Drug rash with eosinophilia and systemic symptoms

Warrington and Silviu-Dan Allergy, Asthma & Clinical Immunology 2011 7(Suppl 1):S10   doi:10.1186/1710-1492-7-S1-S10

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