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Open Access Letter to the editor

Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?

Camila Alexandrina Figueiredo1, Laura Cunha Rodrigues2, Neuza Maria Alcantara-Neves1, Philip J Cooper34, Leila Denise Amorim5, Nivea Bispo Silva5, Alvaro A Cruz6 and Mauricio Lima Barreto7*

Author Affiliations

1 Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil

2 London School of Hygiene and Tropical Medicine, London, UK

3 Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK

4 Colegio de Ciencias de La Salud, Universidad San Francisco de Quito, Quito, Ecuador

5 Instituto de Matemática, Universidade Federal da Bahia, Salvador, Brazil

6 ProAR – Núcleo de Excelência em Asma, Universidade Federal da Bahia and CNPq, Salvador, Brazil

7 Instituto de Saúde Coletiva, Universidade Federal de Bahia, Rua Basilio da Gama s/n, Canela, 41110-040, Salvador-Bahia, Brazil

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Allergy, Asthma & Clinical Immunology 2012, 8:18  doi:10.1186/1710-1492-8-18

Published: 19 December 2012

Abstract

In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-γ) and Th2 (IL-5 and IL-13) cytokines in Dermatophagoides pteronyssinus stimulated peripheral blood leukocytes, blood cell count, skin prick test and specific IgE against common aeroallergens. Atopic status was associated with eosinophilia and production of Th2 type cytokines. Atopic asthma was associated with eosinophilia and non-atopic asthma was associated with IFN-γ and elevated monocytes in blood. IFN-γ and monocytes might play a role in immunopathology of non-atopic asthma in Latin American children.

Keywords:
Non-atopic asthma; Cytokines; IFN-g; Monocytes; Atopic-asthma; IgE; Atopy