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Open Access Research

Immunostimulatory activity of Stachys mialhesi de Noé

Assia Benmebarek1*, Sakina Zerizer1, Souheila Laggoune2 and Zahia Kabouche2

Author Affiliations

1 Laboratoire de Génie microbiologie et application, Equipe: biologie moléculaire et cellulaire. Faculté des sciences, Université de Constantine 1, Constantine, Algeria

2 Laboratoire d’obtention de substances thérapeutiques (Lost), Université de- Constantine 1, Laboratoire d’Obtention de Substances Thérapeutiques (L.O.S.T), Campus Chaabat Ersas, Constantine, 25000, Algeria

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Allergy, Asthma & Clinical Immunology 2013, 9:2  doi:10.1186/1710-1492-9-2

Published: 11 January 2013

Abstract

Background

Immunostimulatory therapy is now being recognized as an alternative to conventional chemotherapy for a variety of disease conditions, involving the impaired immune response of the host. In the present study, the immunostimulatory effect of the butanolic extract obtained from S. mialhesi aerial parts, was evaluated in vivo.

Methods

The immunostimulant potential of the plant extract on the phagocytic activity was measured by the carbon clearance rate test.

Results

Our research revealed that at different doses (50, 100 and 500 mg/kg), S. mialhesi extract increased the phagocytic activity in a dose dependant manner when compared with the control and thus the clearance rate of carbon was faster after the administration of the plant extract.

Conclusion

S. mialhesi extract exhibited a dose-dependent immunostimulant effect on the reticuloendothelial system, which could be attributed to the presence of active principles in this butanolic extract.

Keywords:
Immunostimulatory activity; Phagocytic activity; Carbon clearance rate; Reticuloendothelial system; Stachys mialhesi de Noé